Blood Music Read Free Page B

with each other and develop their intellects.
    The idea of an intellectual cell was still wonderfully strange to him. It made him stop and stand, staring at the wall, until he jerked back to attention and continued his work.
    He pulled up a microscope and inserted a pipette into one of the tubes. The calibrated instrument drew up the dialed amount of fluid and he expelled it into a thin circular ring on a glass slide.
    From the very beginning, Vergil had known his ideas were neither far-out nor useless. His first three months at Genetron, helping establish the silicon-protein interface for the biochips, had convinced him the project designers had missed something very obvious and extremely interesting.
    Why limit oneself to silicon and protein and biochips a hundredth of a millimeter wide, when in almost every living cell there was already a functioning computer with a huge memory? A mammalian cell had a DNA complement of several billion base pairs, each acting as a piece of information. What was reproduction, after all, but a computerized biological process of enormous complexity and reliability?
    Genetron had not yet made the connection, and Vergil had long ago decided he didn’t want them to. He would do his work, prove his point by creating billions of capable cellular computers, and then leave Genetron and establish his own lab, his own company.
    After a year and a half of preparation and study, he had begun working at night on the gene machine. Using a computer keyboard, he constructed strings of bases to form codons, each of which became the foundation of a rough DNA-RNA-protein logic.
    The earliest biologic strings had been inserted into E. coli bacteria as circular plasmids. The E. coli had absorbed the plasmids and incorporated them into their original DNA. The bacteria had then duplicated and released the plasmids, passing on the biologic to other cells. In the most crucial phase of his work, Vergil had used viral reverse-transcriptase to fix the feedback loop between RNA and DNA. Even the earliest and most primitive biologic-equipped bacteria had employed reverse transcriptase as “encoders,” ribosomes as “readers,” and RNA as “tape.” With the loop in place, the cells developed their own memory and the ability to process and act upon environmental information.
    The real surprise had come when he tested his altered microbes. The computing capacity of even bacterial DNA was enormous compared to man-made electronics. All Vergil had to do was take advantage of what was already there-just give it a nudge, as it were.
    More than once, he had the spooky feeling that his work was too easy, that he was less a creator and more a servant…This, after having the molecules seem to fall into their proper place, or fail in such a way that he clearly saw his errors and knew how to correct them.
    The spookiest moment of all came when he realized he was doing more than creating little computers. Once he started the process and switched on the genetic sequences which could compound and duplicate the biologic DNA segments, the cells began to function as autonomous units. They began to “think” for themselves and develop more complex “brains.”
    His first E. coli mutations had had the learning capacity of planarian worms; he had run them through simple T-mazes giving sugar rewards. They had soon outperformed planarians. The bacteria—lowly prokaryotes—were doing better than multicellular eukaryote! And within months, he had them running more complex mazes at rates—allowing for scale adjustments comparable to those of mice.
    Removing the finest biologic sequences from the altered E. coli, he had incorporated them into B-lymphocytes, white cells from his own blood. He had replaced many intron strings—self-replicating sequences of base pairs that apparently did not code for proteins and that comprised a surprising percentage of any eukaryotic cell’s DNA-with his own special chains. Using artificial proteins and